Daniele Dell'Orco Selected Research

Guanylate Cyclase (Guanylyl Cyclase)

11/2023	Recombinant protein delivery enables modulation of the phototransduction cascade in mouse retina.
10/2021	A Novel GUCA1A Variant Associated with Cone Dystrophy Alters cGMP Signaling in Photoreceptors by Strongly Interacting with and Hyperactivating Retinal Guanylate Cyclase.
12/2015	Two retinal dystrophy-associated missense mutations in GUCA1A with distinct molecular properties result in a similar aberrant regulation of the retinal guanylate cyclase.
6/2010	Involvement of the calcium sensor GCAP1 in hereditary cone dystrophies.
3/2010	Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy.

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Daniele Dell'Orco Research Topics

Disease

6	Retinal Dystrophies 01/2024 - 12/2015
5	Cone-Rod Dystrophies 11/2023 - 06/2010
5	Cone Dystrophy 10/2021 - 03/2010
4	Cardiac Arrhythmias (Arrythmia) 12/2023 - 01/2022
3	Retinitis Pigmentosa (Pigmentary Retinopathy) 01/2024 - 01/2020
2	Inborn Genetic Diseases (Disease, Hereditary) 11/2023 - 01/2016
2	Retinal Degeneration 10/2020 - 12/2015
2	Macular Degeneration (Age-Related Maculopathy) 01/2017 - 12/2015
2	Neoplasms (Cancer) 10/2016 - 08/2014
1	Neurodevelopmental Disorders 04/2024
1	Sensorineural Hearing Loss 01/2024
1	Hearing Loss (Hearing Impairment) 01/2024
1	Cystic Fibrosis (Mucoviscidosis) 11/2023
1	Cardiotoxicity 01/2023
1	Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy) 01/2022
1	Choroidal Neovascularization 02/2021
1	Late-Onset Retinal Degeneration 02/2021
1	Photophobia (Light Sensitivity) 12/2020
1	Lipedema 08/2020
1	Mood Disorders (Mood Disorder) 08/2020
1	Nonsyndromic Deafness 12/2019
1	Rare Diseases (Rare Disease) 01/2018
1	Primary Hyperoxaluria (Oxaluria, Primary) 01/2018
1	Retinal Diseases 06/2015
1	Acquired Immunodeficiency Syndrome (AIDS) 07/2013
1	Night Blindness (Nyctalopia) 01/2013

Drug/Important Bio-Agent (IBA)

13	Proteins (Proteins, Gene)FDA Link 04/2024 - 06/2015
7	CalciumIBA 10/2020 - 03/2010
6	Retinaldehyde (Retinal)IBA 01/2024 - 12/2015
5	Guanylate Cyclase (Guanylyl Cyclase)IBA 11/2023 - 03/2010
4	Calmodulin (Calcium-Dependent Activator Protein)IBA 12/2023 - 01/2022
4	Guanylate Cyclase-Activating ProteinsIBA 03/2022 - 10/2014
3	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 01/2023 - 01/2022
2	Codon (Codons)IBA 01/2024 - 01/2022
2	Amino Acids FDA Link 01/2024 - 01/2016
2	EnzymesIBA 12/2015 - 07/2013
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 11/2023
1	Liposomes (Liposome)IBA 11/2023
1	CationsIBA 01/2023
1	Aspartic Acid (Aspartate)FDA Link 03/2022
1	Histidine (L-Histidine)FDA Link 03/2022
1	NucleotidesIBA 01/2022
1	GTP Phosphohydrolases (GTPases)IBA 01/2022
1	SteroidsIBA 08/2020
1	Neurotransmitter Agents (Neurotransmitter)IBA 08/2020
1	Aldo-Keto ReductasesIBA 08/2020
1	plastinIBA 12/2019
1	Vitamin B 6IBA 01/2018
1	Alanine-glyoxylate transaminase (alanine-glyoxylate aminotransferase)IBA 01/2018
1	HeterochromatinIBA 10/2016
1	CytokinesIBA 10/2016
1	Cyclic GMPIBA 12/2015
1	Transcription Factors (Transcription Factor)IBA 08/2014
1	guanylate cyclase 1IBA 07/2013
1	TransducinIBA 01/2013

Therapy/Procedure

1	Therapeutics 11/2023